Thomas hospital trust, london, uk accepted 20 october 2009. Salivary gland tumors are abnormal cells growing in the gland or in the tubes ducts that drain the salivary glands. Although we know a few things that can raise a persons risk of salivary gland cancer, its not clear exactly what causes most of these cancers cancer is caused by changes in the dna inside of cells. Tumors of minor salivary glands e583 introduction salivary gland neoplasms represent less than 1% of all tumors, and 35% of all head and neck neoplasms. They commonly present as a painless and slowly evolving neck mass. Tumors mostly involve the major salivary glands, 42. Salivary gland neoplasm an overview sciencedirect topics. Avoiding some of the possible risk factors such as tobacco, excess alcohol use, and unhealthy diets might slightly lower the likelihood of developing salivary gland cancer, but no one knows for sure. Classification difficult because most tumors arise from or differentiate to epithelial or myoepithelial cells, which can undergo various metaplastic changes oncocytic, chondroid, squamous, sebaceous. Their complexity is attributed to heterogeneity of the cells of origin of these lesions. Benign tumour polymorphous low grade adenocarcinoma plga rare lesion 23% of benign s. The salivary glands are classified as major or minor. These are commonly seen in the cheek, palate, and lips. For the pathologist, it is this differentiation process and the architectural arrangement of the tumor cells that are the keys to classifying a particular salivary gland tumor.
Pleomorphic adenoma common benign tumor and muc tumor. Build on previous arrocases for salivary gland tumors. Salivary gland tumors, like tumors arising in other tissues, are classed on the basis of the differentiation properties of the tumor cells. For malignant tumors, treatment is with excision and radiation. Worrisome clinical symp toms eg, pain, hard consistency, rapid tumor growth. Pathology outlines primary salivary gland neoplasms.
Salivary gland neoplasms make up 6% of all head and neck tumors. Parotid glands located lateral to the mandibular ramus and masseter muscle. Minor salivary gland tumors are uncommon, accounting for up to 15% of salivary gland neoplasms. Below the jaw, there are three main pairs of these glands. About 85% of salivary gland tumors occur in the parotid glands, followed by the submandibular and minor salivary glands, and about 1% occur in the sublingual glands.
However, we do know that avoiding these factors can help reduce your risk of. Saliva works to lubricate the passageway that brings food down into the stomach. Salivary gland tumors sgt are rare neoplasms that generate interest due to their histopathological diversity and clinical behavior. Salivary gland tumours or neoplasms are tumours that form in the tissues of salivary glands. Types of salivary gland cancer memorial sloan kettering. The smaller the salivary gland, the higher the rate of malignancy. Histogenesis of salivary gland neoplasms dwivedi n.
Ppt salivary gland tumors powerpoint presentation free to. This is the most common salivary gland malignancy 2025 per cent of all malignant salivary gland neoplasms, occurs at mucosal sites more frequently than in major salivary glands, and accounts for 26 per cent of parotid tumours and approximately 15 per cent of submandibular tumours. Ppt salivary gland tumors powerpoint presentation free. Minor salivary gland tumors radiology reference article. Which type of salivary gland cancer you have depends on the type of cell where the cancer began. Neoplasms that arise in the salivary glands are relatively rare, yet they represent a wide variety of both benign and malignant histologic subtypes as seen in the image below. Although researchers have learned much from the study of this diverse group of tumors over the years, the diagnosis and treatment of salivary gland neoplasms remain com. Salivary gland tumors ent doctor cancer specialist. The american joint committee for cancer staging and end result reporting ajcc has published a tumor, node, and metastases tnmbased staging system for major salivary gland malignancies. Salivary gland tumors develop within the salivary glands. Dna is the chemical in each of our cells that makes up our genes the instructions for how our cells function. Salivary gland tumors merck manuals professional edition.
Salivary gland tumors information mount sinai new york. We usually look like our parents because they are the source of our dna. Original article histopathological study of salivary gland. Pdf salivary gland tumours are a relatively rare and morphologically diverse group of lesions. Mar 18, 2019 salivary gland neoplasms most commonly appear in the sixth decade of life. Salivary gland tumours are rare and most cases are referred to the head and neck clinic. Salivary gland tumors are one of the most complex and relatively rare group of lesions encountered in oral pathology practice. Surgical management of minor salivary gland neoplasms of the. Salivary gland tumors are a rare and morphologically diverse group of. Surgical management of minor salivary gland neoplasms of.
Salivary gland tumors sgts are rare neoplasms accounting for 0. Benign and malignant salivary gland tumours are clinically heterogeneous and show different histology. Hpv infection, but not ebv or hhv8 infection, is associated. Histogenesis of salivary gland neoplasms dwivedi n, agarwal a.
Classification difficult because most tumors arise from or differentiate to epithelial or myoepithelial cells, which can undergo various metaplastic. Salivary gland dysfunction refers to either xerostomia the symptom of dry mouth or salivary gland hypofunction reduced production of saliva. Their complexity is attributed to heterogeneity of the cells of. There are a variety of benign salivary gland tumors, including. Tumours of the salivary glands display a wide variety of histological appearances, and vary in. Aug 24, 2009 salivary gland neoplasms slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Description the tongue, cheeks, and palate the hard and soft areas at the roof of the mouth contain many glands that produce saliva. A painless salivary mass is the most common sign and is evaluated by fineneedle aspiration biopsy. Series 4 4th edition by gary l ellis author, paul l auclair author. The annual incidence of salivary gland cancers ranges from 0.
Learn vocabulary, terms, and more with flashcards, games, and other study tools. Minor salivary gland tumors are a subtype of salivary gland tumors originating from the minor salivary glands, which are found in the lips, tongue, hard palate, and the mucosa of the oropharynx and larynx, among other locations epidemiology. Little is known about the role of human herpes virus 8 hhv8, epsteinbarr virus ebv, and human papillomavirus hpv infection in salivary gland neoplasms. Because we dont know what causes most salivary gland cancers, we dont yet know how to prevent many of them. Simpson department of histopathology, postgraduate medical school, university of exeter, exeter, england summary. Radiotherapy if a salivary gland tumour is cancerous, radiation therapy may be necessary. Oct 16, 2018 intraoral minor salivary gland tumors constitute both benign and malignant tumors of the minor salivary glands. In case of a tumor, hemangioma is the most common histotype within the salivary glands in these patients baker and malone 1985. Pathogenesis and histogenesis of salivary gland tumours by. Inflammatory tumors and benign cysts represent the major cause of salivary gland enlargements in children. Salivary gland tumors represent 2 to 3% of all head and neck neoplasms. Benign tumors tumor we re more common in submandibular gland. Histogenesis of salivary gland pleomorphic adenoma mixed. Most of these tumors are benign not cancer, but the parotid glands still are where most malignant cancerous salivary gland tumors start.
Tumors of minor salivary glands med oral patol oral cir bucal. Most salivary gland tumors are benign and occur in the parotid glands. The cystic lesion has a mildly fibrotic appearing wall, is lined by histiocytes intermixed with rare lymphocytes, and contains mucous and macrophages. Minor salivary gland carcinoma consider the lip and oral cavity, nasal. To create a sonographic scoring model in the prediction of major salivary gland tumors and to.
The difficulty distinguishing benign tumors from malignancies is a key management challenge for salivary gland carcinomas, particularly those within the parot id glands. Mar 18, 2019 staging of malignant salivary gland tumors is important for predicting prognosis and for accurate comparison of treatment results. Intraoral minor salivary gland tumors constitute both benign and malignant tumors of the minor salivary glands. Surgical excision represents the standard option in the treatment of resectable tumors of both major and minor salivary glands. Histopathological study of salivary gland tumors 88 int j res med. Still in the us, carcinomas of the major salivary glands comprise 11% of oropharyngeal neoplasms. They do not generally invade adjacent tissues or metastasize, but they can continue to grow and become deforming. Portion of a parotid gland demonstrating multiple foci of sebaceous differentiation.
The minor salivary glands consist of 800 small mucussecreting glands located throughout the lining of the oral cavity. Clinicopathological analysis of salivary gland tumors over. Gonsai3 1resident, 2additional professor, 3professor and head, department of pathology, b. Msgts account for 15% of all salivary gland tumors. Fast neutron therapy has been used successfully to treat salivary gland tumors, and has shown to be significantly more effective than photons in studies treating unresectable salivary gland tumors. Salivary gland tumors msd manual professional edition.
Salivary gland tumors is the property of its rightful owner. Although, overall, tumours are more common in the parotid, the incidence of malignancy is higher in the submandibular and minor salivary glands. Fnac is a simple quick inexpensive and minimally invasive technique to. Here you can find more information on the different types of salivary gland. Pdf histogenesis of salivary gland neoplasms shaleen. In children and adolescents, salivary gland tumors make up 0. The sections show a stratified squamous epithelium with a thin layer of parakeratosis, minor salivary glands, and a wellcircumscribed cystic lesion. Salivary gland tumors are rare in comparison to the overall incidence of tumors of the head and neck region. The problem is compounded by the ability of these cells to differentiate and modify. We investigated the presence of the three viruses in formalinfixed, paraffinembedded tissue samples in a cohort of 200 different. Multidisciplinary management of salivary gland cancers. Sep 28, 2017 because we dont know what causes most salivary gland cancers, we dont yet know how to prevent many of them. A total of 87% of benign and 55% of malignant tumors were in the parotid glands, a highly significant predilection p superfacial lobe.
The incidence of salivary gland neoplasms as a whole is approximately 5. The majority of these neoplasms are benign and only 20% are malignant. Salivary gland tumors definition of salivary gland tumors. There are several pairs of salivary glands in different locations a major pair in front of the ears parotid glands.
The overall incidence of salivary gland tumors varies around the world from approximately 0. Thompson salivary glands for dummies 15 benign epithelial tumor comprised of a relatively uniform, monomorphous proliferation of basaloid cells not cell originonly phenotype both duct luminal and myoepithelial cells present dont use monomorphic adenoma about 4% of salivary gland tumors age. We describe our experience with both benign and malignant tumors of the palatal minor salivary glands, focusing on the extent of resection and options for defect reconstruction. Current concepts in diagnosis of unusual salivary gland tumors. The major salivary glands consist of the parotid, submandibular, and sublingual glands. Salivary gland tumors ppt by dr gulzar a bhat authorstream. Following radiotherapy of the head and neck region, salivary gland dysfunction is a. T rise within sg tissue, common parotid 78% composed of cellular elements oncocytes.
About salivary gland cancer what is salivary gland cancer. It is proposed that this class of salivary gland tumor forms a spectrum with monomorphic adenoma and myoepithelioma at the extremes and a wide range of pleomorphic adenoma between, depending on the type and degree of gene expression that is coupled with neoplastic transformation. The majority of salivary gland tumors are benign, meaning they are not cancers. Salivary gland tumors are relatively uncommon and account for approximately 36% of all neoplasms of the head and neck. Tumors of the salivary glands afip atlas of tumor pathology. These tumors are more common in females aged over 40 years. Patients with malignant lesions typically present after age 60 years, whereas those with benign lesions usually present when older than 40 years. This topic discusses the clinical presentation, diagnosis, initial evaluation, and staging of salivary gland tumors. Minor salivary glands located throughout oral cavity, pharynx, and paranasal sinuses. They produce saliva, which moistens food to help with chewing and swallowing. The following tumor types should not be reported using this protocol. The minor salivary gland tumors msgts may be present in individuals of a wide age range including children and adults. The neoplasms occurred more frequently in the parotid gland 65%, followed by submandibular gland 21.
Eighty percent of neoplasms occur in the parotid glands, of which up to 80% are benign. Materials and methods this is a retrospective study carried out from january 2010 to december 2015. Salivary gland tumors definition of salivary gland. Though definitive evidence for the reserve additional types of salivary gland tumors, such as certain cell hypothesis continues to be unavailable. Retrospective study of 124 cases of salivary gland tumors and. Differentiation of benign and malignant tumors is not the primary goal of ct and mri. Mortality from malignant salivary gland neoplasms varies by stage and pathology, but the overall 5year survival rate is 72%.
Malignant sgts represent 6% of head and neck cancers and 0. Aims and objectives the aim of this study is to recognise various histomorphological types of salivary gland tumors, their frequency, age and site distribution. If so, share your ppt presentation slides online with. Epsteinbarr virus the consistent association of ebv with lymphoepithelial carcinoma of the salivary gland suggest the virus probably plays causal role similar pathogenesis of nasopharyngeal carcinoma no evidence of a causal role of ebv in other primary tumors of the salivary gland.
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